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1

A Supramolecular Cytochrome P450 Mimic

Albertus P. H. J. Schenning, Jeffrey H. Lutje Spelberg, Dominicus H. W. Hubert, Martinus C. Feiters, Roeland J. M. Nolte

Journal:

Chemistry - A European Journal

Année:

1998

Langue:

english

Fichier:

PDF, 217 KB

english, 1998

2

Biocatalytic Potential of the Epoxide Hydrolase from Agrobacterium radiobacter AD1 and a Mutant with Enhanced Enantioselectivity

Jeffrey H. Lutje Spelberg, Rick Rink, Alain Archelas, Roland Furstoss, Dick B. Janssen

Journal:

Advanced Synthesis & Catalysis

Année:

2002

Langue:

english

Fichier:

PDF, 100 KB

english, 2002

3

Stereo-Complementary Two-Step Cascades Using a Two-Enzyme System Leading to Enantiopure Epoxides

Birgit Seisser, Iván Lavandera, Kurt Faber, Jeffrey H. Lutje Spelberg, Wolfgang Kroutil

Journal:

Advanced Synthesis & Catalysis

Année:

2007

Langue:

english

Fichier:

PDF, 96 KB

english, 2007

4

Catalytic Promiscuity of Halohydrin Dehalogenase and its Application in Enantioselective Epoxide Ring Opening

Ghannia Hasnaoui-Dijoux, Maja Majerić Elenkov, Jeffrey H. Lutje Spelberg, Bernhard Hauer, Dick B. Janssen

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 171 KB

english, 2008

5

Cover Picture: Catalytic Promiscuity of Halohydrin Dehalogenase and its Application in Enantioselective Epoxide Ring Opening (ChemBioChem 7/2008)

Ghannia Hasnaoui-Dijoux, Maja Majerić Elenkov, Jeffrey H. Lutje Spelberg, Bernhard Hauer, Dick B. Janssen

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 840 KB

english, 2008

6

Directed Evolution of Epoxide Hydrolase from A. radiobacter toward Higher Enantioselectivity by Error-Prone PCR and DNA Shuffling

Bert van Loo, Jeffrey H.Lutje Spelberg, Jaap Kingma, Theo Sonke, Marcel G Wubbolts, Dick B Janssen

Journal:

Chemistry & Biology

Année:

2004

Langue:

english

Fichier:

PDF, 278 KB

english, 2004

7

Whole-cell biocatalysis: Evaluation of new hydrophobic ionic liquids for efficient asymmetric reduction of prochiral ketones

Stefan Bräutigam, Danielle Dennewald, Melanie Schürmann, Jeffrey Lutje-Spelberg, William-Robert Pitner, Dirk Weuster-Botz

Journal:

Enzyme and Microbial Technology

Année:

2009

Langue:

english

Fichier:

PDF, 741 KB

english, 2009

8

Improved enantioselective conversion of styrene epoxides and meso-epoxides through epoxide hydrolases with a mutated nucleophile-flanking residue

Bert van Loo, Jaap Kingma, Gertjan Heyman, Alex Wittenaar, Jeffrey H. Lutje Spelberg, Theo Sonke, Dick B. Janssen

Journal:

Enzyme and Microbial Technology

Année:

2009

Langue:

english

Fichier:

PDF, 960 KB

english, 2009

9

Microbiological transformations. Part 48: Enantioselective biohydrolysis of 2-, 3- and 4-pyridyloxirane at high substrate concentration using the Agrobacterium radiobacter AD1 epoxide hydrolase and its Tyr215Phe mutant

Yvonne Genzel, Alain Archelas, Jeffrey H Lutje Spelberg, Dick B Janssen, Roland Furstoss

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 99 KB

english, 2001

10

The enantioselectivity of haloalkane dehalogenases

Roland J Pieters, Jeffrey H Lutje Spelberg, Richard M Kellogg, Dick B Janssen

Journal:

Tetrahedron Letters

Année:

2001

Langue:

english

Fichier:

PDF, 80 KB

english, 2001

11

Improved stability of halohydrin dehalogenase from Agrobacterium radiobacter AD1 by replacement of cysteine residues

Lixia Tang, Johan E.T van Hylckama Vlieg, Jeffrey H Lutje Spelberg, Marco W Fraaije, Dick B Janssen

Journal:

Enzyme and Microbial Technology

Année:

2002

Langue:

english

Fichier:

PDF, 215 KB

english, 2002

12

Exploration of the biocatalytic potential of a halohydrin dehalogenase using chromogenic substrates

Jeffrey H Lutje Spelberg, Lixia Tang, Marc van Gelder, Richard M Kellogg, Dick B Janssen

Journal:

Tetrahedron: Asymmetry

Année:

2002

Langue:

english

Fichier:

PDF, 257 KB

english, 2002

13

Enantioselectivity of a recombinant epoxide hydrolase from Agrobacterium radiobacter

Jeffrey H.Lutje Spelberg, Rick Rink, Richard M. Kellogg, Dick B. Janssen

Journal:

Tetrahedron: Asymmetry

Année:

1998

Langue:

english

Fichier:

PDF, 107 KB

english, 1998

14

A tandem enzyme reaction to produce optically active halohydrins, epoxides and diols

Jeffrey H. Lutje Spelberg, Johan E.T. van Hylckama Vlieg, Tjibbe Bosma, Richard M. Kellogg, Dick B. Janssen

Journal:

Tetrahedron: Asymmetry

Année:

1999

Langue:

english

Fichier:

PDF, 141 KB

english, 1999

15

Discovery of a thermostable Baeyer–Villiger monooxygenase by genome mining

Marco W. Fraaije, Jin Wu, Dominic P. H. M. Heuts, Erik W. van Hellemond, Jeffrey H. Lutje Spelberg, Dick B. Janssen

Journal:

Applied Microbiology and Biotechnology

Année:

2005

Langue:

english

Fichier:

PDF, 368 KB

english, 2005

16

Enzymatic dynamic kinetic resolution of epihalohydrins

Jeffrey H Lutje Spelberg, Lixia Tang, Richard M Kellogg, Dick B Janssen

Journal:

Tetrahedron: Asymmetry

Année:

2004

Langue:

english

Fichier:

PDF, 309 KB

english, 2004

17

Nitrite-mediated hydrolysis of epoxides catalyzed by halohydrin dehalogenase from Agrobacterium radiobacter AD1: a new tool for the kinetic resolution of epoxides

Ghannia Hasnaoui, Jeffrey H. Lutje Spelberg, Erik de Vries, Lixia Tang, Bernhard Hauer, Dick B. Janssen

Journal:

Tetrahedron: Asymmetry

Année:

2005

Langue:

english

Fichier:

PDF, 176 KB

english, 2005

18

Shifting the equilibrium of a biocatalytic cascade synthesis to enantiopure epoxides using anion exchangers

Joerg H. Schrittwieser, Iván Lavandera, Birgit Seisser, Barbara Mautner, Jeffrey H. Lutje Spelberg, Wolfgang Kroutil

Journal:

Tetrahedron: Asymmetry

Année:

2009

Langue:

english

Fichier:

PDF, 373 KB

english, 2009

19

Enzyme Mimic Displaying Oscillatory Behavior. Oscillating Reduction of Manganese(III) Porphyrin in a Membrane-Bound Cytochrome P-450 Model System

Schenning, Albertus, Lutje Spelberg, Jeffrey, Driessen, Martijn, Hauser, Marcus, Feiters, Martinus, Nolte, Roeland

Journal:

Journal of the American Chemical Society

Année:

1995

Langue:

english

Fichier:

PDF, 912 KB

english, 1995

20

Kinetic Mechanism and Enantioselectivity of Halohydrin Dehalogenase from Agrobacterium radiobacter †

Tang, Lixia, Lutje Spelberg, Jeffrey H., Fraaije, Marco W., Janssen, Dick B.

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 136 KB

english, 2003

21

Tyrosine Residues Serve as Proton Donor in the Catalytic Mechanism of Epoxide Hydrolase from Agrobacterium radiobacter

Rink, Rick, Kingma, Jaap, Lutje Spelberg, Jeffrey H., Janssen, Dick B.

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 181 KB

english, 2000

22

Highly Enantioselective and Regioselective Biocatalytic Azidolysis of Aromatic Epoxides

Lutje Spelberg, Jeffrey H., van Hylckama Vlieg, Johan E. T., Tang, Lixia, Janssen, Dick B., Kellogg, Richard M.

Journal:

Organic Letters

Année:

2001

Langue:

english

Fichier:

PDF, 39 KB

english, 2001

23

Mutation of Tyrosine Residues Involved in the Alkylation Half Reaction of Epoxide Hydrolase from Agrobacterium radiobacter AD1 Results in Improved Enantioselectivity

Rink, Rick, Lutje Spelberg, Jeffrey H., Pieters, Roland J., Kingma, Jaap, Nardini, Marco, Kellogg, Richard M., Dijkstra, Bauke W., Janssen, Dick B.

Journal:

Journal of the American Chemical Society

Année:

1999

Langue:

english

Fichier:

PDF, 43 KB

english, 1999

24

Steady-State Kinetics and Tryptophan Fluorescence Properties of Halohydrin Dehalogenase from Agrobacterium radiobacter . Roles of W139 and W249 in the Active Site and Halide-Induced Conformational Change †

Tang, Lixia, van Merode, Annet E. J., Lutje Spelberg, Jeffrey H., Fraaije, Marco W., Janssen, Dick B.

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 188 KB

english, 2003